产品货号：
Z22640
中文名称：
NTN1抗体
英文名称：
Anti-NTN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NTN1 Antibody |
| 指标别名 | netrin 1;NTN1;NTN1L;NTN1-Specific |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | NTN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Netrin 1(32-51aa AGQAAQPDPCSDENGHPRRC),identical to the related rat and mouse sequences. |
| 实际分子量 | 68KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Netrin-1(NTN1),also known as NTN1L,is a diffusible protein made by floor plate cells.Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord,as well as other locations in the nervous system including the somatic mesoderm,pancreas and cardiac muscle.The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH.Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro.And netrin-1 expression confers a selective advantage for tumor cell survival.The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins.Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1,and that netrin-1-dependent outgrowth of dorsal spinal cord axons directly involves A2b.Netrin-1 can promote intestinal tumor development,probably by regulating cell survival.Thus,a netrin-1 receptor or receptors function as conditional tumor suppressors.Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro,whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion. |
| Uniprot ID | O95631 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | netrin 1 |
| 蛋白名全称 | Netrin-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：NTN1抗体，NTN1多抗，Anti-NTN1 Antibody